Posted in HWH COMMENTARY, NEWS OF INTEREST

Researchers report novel complementary effects of estrogen treatment in multiple sclerosis

HWH COMMENT > Does this mean that all the vegans/vegetarians who think phytoestrogens in tofu (soy) are as harmful as estrogen not produced by the human body should begin eating tofu again to stave off multiple sclerosis? I’m on board as ridiculous as this all seems, it makes perfect sense to me.

So, an increase in estrogen protects the brain and associated nerves. Yet, some researchers have noted that phytoestrogens in plants are not the same as estrogens in humans – though previous tofu-eaters are staying clear of tofu based on their gut interpretation that the effects are the same.

So if their gut is right (that plant and animal estrogens act the same in nature) then bring on the tofu to prevent brain/nerve damage. Or, taking a stretch here, cure brain/nerve damage. It really doesn’t matter if disease or trauma or something else causes brain/nerve damage. Nerve damage is nerve damage. Fix it. How to.

Okay, fix the damage and you still have a disease that’s going to create more damage. Okay, so with trauma, the trauma ends rather quickly and you have damage. Fix the damage and you’re done. Not so fast. Trauma can become disease-like when a consequent syndrome is associated with it – whether conscious of it or not.

Oh, oh, I’m wondering why after a concussion I start craving tofu. It’s in the refrigerator now. I had some last night, the night before. Had it on Christmas – practically ate the whole plate at a Chinese restaurant, something I rarely do. Can’t stop thinking about what to do next with tofu. Why? When nobody wants it? I want it. I need it. I crave it. Now I’m free to not feel I’m doing my body bad by eating it.

It’s all about protection. If damaged by trauma, nerves are exposed, then something goes awry in the body to keep them from healing while simultaneously the body attacks the weak links to destroy them, thinking it’s helping not hurting, well, that is disease-like.

Keep your myelin sheaths intact.

Eat tofu.

Indulge your myelin sheaths.

Eat soy.

New question > What plants contain phytotestosterone? Why do people want to eat phyotestosterone foods but not phytoestrogen foods? Do I sense a prejudice here? Men don’t want plant estrogen, but women don’t want it either. Men want plant testosterone, but why is it not harmful to them, if plant estrogen is harmful to women? Lots of explaining to do.


December 28, 2017, University of California, Los Angeles

A study by UCLA researchers reveals the cellular basis for how the hormone estrogen protects against damage to the central nervous system in people with multiple sclerosis (MS). The researchers found that estrogen treatment exerts positive effects on two types of cells during disease —immune cells in the brain and also cells called oligodendrocytes. Complementary actions on these two types provide protection from disease.

Multiple sclerosis is a chronic autoimmune, neurodegenerative disease marked by visual impairment, weakness and sensory loss, as well as cognitive decline. These symptoms emerge when inflammatory  destroy the  that surrounds nerve processes called axons. Loss of that protective insulation disrupts electrical communication between .

The third trimester of pregnancy has been previously shown to reduce relapse rates by approximately 70 percent as compared to before pregnancy, and other studies have shown benefit over the long term due to multiple pregnancies. An estrogen unique to pregnancy that is made by the fetus and placenta has been proposed by Dr. Rhonda Voskuhl and colleagues to mediate this pregnancy protection in both the MS mouse model as well as in two successfully completed clinical trials of estriol treatment in MS patients.

How that happens has remained a critical question. Voskuhl, who led the latest study, reported mouse studies showing that estrogen protected the  from damage by activating a protein called estrogen receptor beta (ERb). Her new research identifies which cells within the brain are mediating this protective effect…

READ ON > Researchers report novel complementary effects of estrogen treatment in multiple sclerosis






 

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Posted in NEWS OF INTEREST

Researchers discover mechanism that allows rapid signal transmission between nerve cells

December 14, 2017

Researchers at Charité’s NeuroCure Cluster of Excellence have successfully identified the mechanism behind rapid signal transmission. Their work, published in the current issue of Nature Neuroscience, shows that bridging by a specific protein is responsible for this high speed of transmission.

The manner in which individual communicate is fundamental to human brain function. Signal transmission occurs via highly complex contact points called synapses. Here, incoming signals effect the release of transmitters from stores known as vesicles, which fuse with the adjoining cell membranes in order to transmit the signal. This fusion is only possible once vesicles and membranes have been brought into close enough proximity; here, speed is everything.

“In short, the distance between the and the membrane is a major barrier to rapid fusion,” explains the article’s corresponding author, Prof. Dr. Christian Rosenmund of the Institute of Neurophysiology and the NeuroCure Cluster of Excellence. While the protein synaptotagmin had been known to play an important role in determining the speed of , the nature of the underlying mechanism had previously remained unclear. “We have now found that synaptotagmin is capable of pulling the synaptic vesicles closer to the membrane within a matter of milliseconds. It does this by acting like a double-sided sticky tape, forming a bridge between the vesicle and the membrane,” says Prof. Rosenmund, further explaining that fusion can only occur once this bridge has been formed.

The electron microscopy-based method developed by Prof. Rosenmund was integral to this research, as it allowed researchers to break down in slow motion processes that normally last only milliseconds. The findings themselves were purely coincidental. Dr. Shuwen Chang, a researcher at the Rosenmund Lab and the study’s first author, was meant to use the new electron microscopy-based method for the direct visualization of the vesicle- fusion process. “As it all happens so quickly, we were looking for ways to slow down the process of fusion,” says Dr. Chang. The team decided to reduce the speed of fusion by removing synaptotagmin from the equation. They were surprised to find that this not only slowed the process of fusion, but also resulted in vesicles and membranes remaining farther apart…

READ ON > Researchers discover mechanism that allows rapid signal transmission between nerve cells